Iloprost Attenuates Oxidative Stress-Dependent Activation of Collagen Synthesis Induced by Sera from Scleroderma Patients in Human Pulmonary Microvascular Endothelial Cells

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dc.contributor.authorRoberta Giordo
dc.contributor.authorThuan Duong
dc.contributor.authorAnna Maria Posadino
dc.contributor.authorAnnalisa Cossu
dc.contributor.authorAngelo Zinellu
dc.contributor.authorGian Luca Erre
dc.contributor.authorGianfranco Pintus
dc.date.accessioned2023-09-18T02:54:02Z
dc.date.available2023-09-18T02:54:02Z
dc.date.issued2021-08-05
dc.description.abstractEndothelial cell injury is an early event in systemic sclerosis (SSc) pathogenesis and several studies indicate oxidative stress as the trigger of SSc-associated vasculopathy. Here, we show that circulating factors present in sera of SSc patients increased reactive oxygen species (ROS) production and collagen synthesis in human pulmonary microvascular endothelial cells (HPMECs). In addition, the possibility that iloprost, a drug commonly used in SSc therapy, might modulate the abovementioned biological phenomena has been also investigated. In this regard, as compared to sera of SSc patients, sera of iloprost-treated SSc patients failed to increased ROS levels and collagen synthesis in HPMEC, suggesting a potential antioxidant mechanism of this drug.
dc.identifier.citationGiordo, R.; Thuan, D.T.B.; Posadino, A.M.; Cossu, A.; Zinellu, A.; Erre, G.L.; Pintus, G. Iloprost Attenuates Oxidative Stress-Dependent Activation of Collagen Synthesis Induced by Sera from Scleroderma Patients in Human Pulmonary Microvascular Endothelial Cells. Molecules 2021, 26, 4729. https://doi.org/10.3390/ molecules26164729
dc.identifier.urihttps://vinspace.online/handle/123456789/195
dc.language.isoen
dc.titleIloprost Attenuates Oxidative Stress-Dependent Activation of Collagen Synthesis Induced by Sera from Scleroderma Patients in Human Pulmonary Microvascular Endothelial Cells
dc.typeArticle
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