Imatinib augments standard malaria combination therapy without added toxicity

Simple item page
dc.contributor.authorChien Huynh
dc.contributor.authorAntonella Pantaleo
dc.contributor.authorKristina R. Kesely
dc.contributor.authorPanae Noomuna
dc.contributor.authorKarson S. Putt
dc.contributor.authorTuan Tran
dc.contributor.authorPhilip S. Low
dc.contributor.authorFrancesco M. Turrini
dc.date.accessioned2023-09-18T02:52:01Z
dc.date.available2023-09-18T02:52:01Z
dc.date.issued2021
dc.description.abstractTo egress from its erythrocyte host, the malaria parasite, Plasmodium falciparum, must destabilize the erythrocyte membrane by activating an erythrocyte tyrosine kinase. Because imatinib inhibits erythrocyte tyrosine kinases and because imatinib has a good safety profile, we elected to determine whether coadministration of imatinib with standard of care (SOC) might be both well tolerated and therapeutically efficacious in malaria patients. Patients with uncomplicated P. falciparum malaria from a region in Vietnam where one third of patients experience delayed parasite clearance (DPC; continued parasitemia after 3 d of therapy) were treated for 3 d with either the region’s SOC (40 mg dihydroartemisinin + 320 mg piperaquine/d) or imatinib (400 mg/d) + SOC. Imatinib + SOC-treated participants exhibited no increase in number or severity of adverse events, a significantly accelerated decline in parasite density and pyrexia, and no DPC. Surprisingly, these improvements were most pronounced in patients with the highest parasite density, where serious complications and death are most frequent. Imatinib therefore appears to improve SOC therapy, with no obvious drug-related toxicities.
dc.identifier.urihttps://vinspace.online/handle/123456789/194
dc.language.isoen
dc.titleImatinib augments standard malaria combination therapy without added toxicity
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Imatinib augments standard malaria combination therapy without added toxicity.pdf
Size:
1.98 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
Huynh Dinh Chien